Bronze:
Overtime Sheet: Beat the high score in the "Extraction Site" Challenge
No Cop Duty: Beat the high score in the "Central Plaza" Challenge
Engineer By Trade: Beat the high score in the "Maintenance Bay" Challenge
Laugh It Up Partner: Beat the high score in the "Mess Hall" Challenge
Colony Full Of Crazy People: Beat the high score in the "Medical Bay" Challenge
Need A Towel: Beat the high score in the "Water Tunnels" Challenge
Herbal Remedies: Beat the high score in the "East Grow Chamber" Challenge
Ready For Takeoff: Beat the high score in the "Shuttle Bay 47" Challenge
Bridge Commander: Beat the high score in the "Atrium" Challenge
Got A Medic: Beat the high score in the "Life Support Room" Challenge
You Need Glasses Partner?: Survive the shuttle flight with at least 80% Perfect Reloads
Skill – Reload: Complete a level with at least 80% Perfect Reloads
Skill – Accuray: Complete a level with at least 80% Weapon Accuracy
Skill – Stasis: Complete a level with at least 80% Stasis Accuracy
A Star is Born: Complete a level with a 5-star rating
Rising Star: Earn 10 Stars in a profile
Collector’s Delight: Collect all weapons, text logs and audio logs in Chapter 1 - Worlds Apart
No Stone Unturned: Collect all weapons, text logs and audio logs in Chapter 3 - Return to the Megavents
Scavenger: Collect all weapons, text logs and audio logs in Chapter 5 - Emergency Care
Treasure Hunter: Collect all weapons, text logs and audio logs in Chapter 8 - In the Hearts of Men
Make Us Whole: Collect all weapons, text logs and audio logs in Chapter 9 - Escaping the Ishimura
It Needs Our Help: Complete Chapter 1 - Worlds Apart
That’s Quite A Mouthfoul: Complete Chapter 2 - Another Day at the Office
Figments Of My Imagination: Complete Chapter 3 - Return to the Megavents
Quit Yacking And Start Shooting: Complete Chapter 4 - Rendezvous with Fate
Finally Grow A Pair: Complete Chapter 5 - Emergency Care
Twice The Firepower: Play cooperatively with a second player
Too Much Firepower?: Enter the secret weapon shop in the P-Sec
What Did You Find?: Take a shortcut in the Megavents
Taking Your Time, McNeill?: Admire the view of the destroyed shuttle
Silver:
Survivor: Complete the game on Normal difficulty
P-Sec Officer: Complete the game on Hard difficulty
Necro Slayer: Complete the game on Expert difficulty
Super Star: Get 30 stars on a profile
Gun Dealer: Collect all weapons on one profile
Gold:
Isaac 2.0: Complete the game on Impossible difficulty
Mega Star: Get 50 stars on a profile
Weapon Nut: Fully upgrade all weapons on one profile
Platinum:
Man Up Sweetheart: Unlock all trophies